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Food and Drug Administration (FDA)

Ultimately, it was revealed that cholinergic fibers are present within the subchondral bone of individuals with OA, and the release of acetylcholine (Ach) triggered by vagus nerve stimulation plays a prominent role in combating inflammation across various diseases while also providing pain relief

In recent years, the effects of MSM have received increasing attention in scientific studies

After washing several times in 0.01 M PBS, the samples were treated with anti-rabbit IgG antibodies (Thermo Fisher Scientific) in 0.01 M PBS at 22 2 C for 1 h

It cannot be used directly for FDA new drug applications